Jonathan Taylor rushed for 170 yards, including a game-clinching 67-yard touchdown and EJ Speed scored on a blocked punt return as the Indianapolis Colts posted a 27-17 victory over the visiting New England Patriots.

Nyheim Hines scored a touchdown and Matthew Adams blocked the critical punt as the Colts (8-6) won for the fifth time in six games.

Darius Leonard had an interception and forced fumble to go along with 10 tackles, and Indianapolis built a 20-point lead before holding off the New England charge.

Taylor, who carried the ball 29 times, topped 100 yards for the eighth time this season and the Colts have won each game.

Indianapolis also snapped an eight-game losing skid against the Patriots, a streak that includes playoff losses in the 2013 and 2014 seasons.

Mac Jones completed 26 of 45 passes for 299 yards, two touchdowns and two interceptions for New England (9-5), which had its seven-game winning streak halted.

Hunter Henry had six receptions for 77 yards and two touchdowns.

The Colts hadn't allowed a point in seven straight quarters until the Patriots came alive in the final quarter.

Jones tossed a 12-yard scoring pass to Henry on the first play and Nick Folk added a 25-yard field goal with 8 minutes 57 seconds remaining.

Henry caught a 7-yard scoring pass with 2:21 remaining as New England crept within 20-17.

But with the Patriots selling out on the run, Taylor got through the line of scrimmage and was in the clear on the decisive run for his 19th total touchdown of the season, one off the franchise record set by Baltimore Colts legend Lenny Moore in 1964.